Rising Interest in Ultra-High Pressure Liquid Chromatography

I am happy to report that the second issue of The Pharmaceutical Sciences, Manufacturing & Marketplace Report eNewsletter will be coming out this week.

With the PITTCON Conference & Expo coming up March 17-21 in Philadelphia, we have made pharmaceutical analysis are featured community.  Specifically, we asked ultra-high pressure liquid chromatography (UHPLC) instrument manufacturers to comment on why there is such a growing interest in this analytical technology, what its current limitations are, and what the future might hold.

They see the use of UHPLC as improving profitability through increased throughput, both in the R&D and development phases and for production batch analyses. UHPLC also enables online monitoring and multi-residue analyses. Do you agree? How are you benefiting from the use of UHPLC?

With respect to limitations, most see workflow as the major issue, with sample preparation a particular bottleneck for many companies. Automation is suggested as a way of addressing this issue. Do you think it will have a real impact? They also point to the need for enhancement in selective detection technologies. Do you have other issues with UHPLC?

Finally, do you see UHPLC becoming a universal separation method?

In this second issue of The Pharmaceutical Sciences, Manufacturing & Marketplace Report eNewsletter, you will also find stories about pre-filled syringes, the agreement between DSM Pharmaceutical Products and The Almac Group to share their enzyme  biocatalysis expertise and assets for more effective route development and scale up, a collaboration by The Dow Chemical Company and Bend Research for the development and commercialization of new materials for spray-dried dispersions of poorly soluble drugs, and a specially designed reactor from ATMI for larger scale production of fragile cells.

Are any of these topics of importance to you? Are you, for example, interested in screening biocatalysts earlier in the development phase, but not sure how to proceed? Are you looking for improved processes for the preparation of spray-dried dispersions? Perhaps you have a stem-cell base product but its development has been stalled due to lack of a practical means for scale-up. What are your concerns?

Help start a conversation. New thoughts and ideas are needed for innovation to take place. Raw materials and excipient producers, equipment manufacturers, and CMOs and CDMOs need your input in order to develop the products and services that will maximize your productivity, efficiency, and quality. Let them know what is important to you.

And look for the second issue of The Pharmaceutical Sciences, Manufacturing & Marketplace Report this week. If you haven’t signed up to receive it yet, take the opportunity right now. Just click here.

Cynthia A. Challener, PhD

Editor

The Pharmaceutical Sciences, Manufacturing & Marketplace Report