Any
analytical method that can be carried out without damaging the samples is
attractive for pharmaceutical manufacturers. It is not surprising, therefore,
that interest is growing in industrial X-ray analysis. This nondestructive
analytical technique offers both depth of
penetration and reasonably high resolution, making it possible to capture the
internal geometric data of a sample along with its density distribution,
information that can be useful for process and design verification, product-quality
analysis, foreign-material determination (metal, glass, organics), fill-level
confirmation, and missing-components detection. In addition, with
three-dimensional computed tomography imaging, it is possible to get a true
three-dimensional view of the inside of a tablet, capsule, gelcap, or any type
of solid or semisolid dosage form. Packaging materials–from medicine bottles to
syringes–can also be evaluated.
What
is your experience withX-ray analysis of solid or semi-solid dosage forms? Have
you found it useful for identifying the source of inconsistencies in the
disintegration of fast-dissolve formulations, or perhaps the improper
functioning of your syringes or pill container seals? What other applications
might there be for X-ray imaging in pharmaceutical manufacturing? What are its
limitations? How might it be improved?
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Also check out the Pharmaceutical Technology/Biopharm International Marketplace
at www.pharmabiomarketplace.com.
Cynthia Challener, PhD
Editor
The
Pharmaceutical Sciences, Manufacturing & Marketplace Report
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